Error detection in proofreading
نویسندگان
چکیده
منابع مشابه
Speed, dissipation, and error in kinetic proofreading.
Proofreading mechanisms increase specificity in biochemical reactions by allowing for the dissociation of intermediate complexes. These mechanisms disrupt and reset the reaction to undo errors at the cost of increased time of reaction and free energy expenditure. Here, we draw an analogy between proofreading and microtubule growth which share some of the features described above. Our analogy re...
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For robust molecular implementation of tile-based algorithmic self-assembly, methods for reducing errors must be developed. Previous studies suggested that by control of physical conditions, such as temperature and the concentration of tiles, errors (ε) can be reduced to an arbitrarily low rate – but at the cost of reduced speed (r) for the self-assembly process. For tile sets directly implemen...
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The ribosome uses initial and proofreading selection of aminoacyl-tRNAs for accurate protein synthesis. Anomalously high initial misreading in vitro of near-cognate codons by tRNA(His) and tRNA(Glu) suggested potential error hotspots in protein synthesis, but in vivo data suggested their partial neutralization. To clarify the role of proofreading in this error reduction, we varied the Mg(2+) io...
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Proofreading text relies on stored knowledge, language processing, and attentional resources. Age differentially affects these constituent abilities: while older adults maintain word knowledge and most aspects of language comprehension, language production and attention capacity are impaired with age. Research with young adults demonstrates that proofreading is more attentionally-demanding for ...
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The aim of this paper is to propose some diagnostic methods in linear ridge measurement error models with stochastic linear restrictions using the corrected likelihood. Based on the bias-corrected estimation of model parameters, diagnostic measures are developed to identify outlying and influential observations. In addition, we derive the corrected score test statistic for outliers detection ba...
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ژورنال
عنوان ژورنال: Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie
سال: 1986
ISSN: 2222-4173,0254-3486
DOI: 10.4102/satnt.v5i2.978